The UNAIDS 2016–2021 Strategy is a bold call to action to get on the Fast-Track and reach people being left behind. It is an urgent call to front-load investments. It is a call to reach the 90–90–90 treatment targets, to close the testing gap and to protect the health of the 22 million people living with HIV who are still not accessing treatment. It is a call to redress the deplorably low treatment coverage for children living with HIV.